Petzold, Axel;
Fraser, Clare L;
Abegg, Mathias;
Alroughani, Raed;
Alshowaeir, Daniah;
Alvarenga, Regina;
Andris, Cécile;
... Plant, Gordon T; + view all
(2022)
Diagnosis and classification of optic neuritis.
The Lancet Neurology
, 21
(12)
pp. 1120-1134.
10.1016/s1474-4422(22)00200-9.
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Abstract
There is no consensus regarding the classification of optic neuritis, and precise diagnostic criteria are not available. This reality means that the diagnosis of disorders that have optic neuritis as the first manifestation can be challenging. Accurate diagnosis of optic neuritis at presentation can facilitate the timely treatment of individuals with multiple sclerosis, neuromyelitis optica spectrum disorder, or myelin oligodendrocyte glycoprotein antibody-associated disease. Epidemiological data show that, cumulatively, optic neuritis is most frequently caused by many conditions other than multiple sclerosis. Worldwide, the cause and management of optic neuritis varies with geographical location, treatment availability, and ethnic background. We have developed diagnostic criteria for optic neuritis and a classification of optic neuritis subgroups. Our diagnostic criteria are based on clinical features that permit a diagnosis of possible optic neuritis; further paraclinical tests, utilising brain, orbital, and retinal imaging, together with antibody and other protein biomarker data, can lead to a diagnosis of definite optic neuritis. Paraclinical tests can also be applied retrospectively on stored samples and historical brain or retinal scans, which will be useful for future validation studies. Our criteria have the potential to reduce the risk of misdiagnosis, provide information on optic neuritis disease course that can guide future treatment trial design, and enable physicians to judge the likelihood of a need for long-term pharmacological management, which might differ according to optic neuritis subgroups.
| Type: | Article |
|---|---|
| Title: | Diagnosis and classification of optic neuritis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/s1474-4422(22)00200-9 |
| Publisher version: | https://doi.org/10.1016/s1474-4422(22)00200-9 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Optic neuritis, optiese neuritis, neuritit optik, neuritis óptica, неўрытаў глядзельнага нерва, optičkog neuritisa, оптичния неврит, optického neuritidy, optisk neuritis, optische neuritis, optilise neuriidi, optisen neuriitin, névrite optique, optikusneuritis, οπτικής νευρίτιδας, neurit optik, neuritis na gani, neuritis optic, látóideggyulladás, sjóntaugabólgu, neuritis optik, neurite ottica, neuritis optik, көру невритінің, neurite optique, optik nyuraytis оптикалык невриттин, neuritis opticorum, optiskā neirīta, regos nervo neurito, оптички невритис, нүдний мэдрэлийн, optisk nevrit, dhukkuba niwuraayitii ijaa, zapalenia nerwu wzrokowego, neurite óptica, neuritis óptica nisqamanta, nevritei optice, неврита зрительного нерва, nevritei optice, оптичког неуритиса, zápalu zrakového nervu, optičnega nevritisa, neuritis-ka indhaha, neuritis ya macho, неврити оптикӣ, оптик нейрит, optik nöritin, optiki neýritiň, optik nevritning, neuritis opiki |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10156457 |
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