Christie, Isabel N;
Windsor, Rowan;
Mutsaerts, Henk JMM;
Tillin, Therese;
Sudre, Carole H;
Hughes, Alun D;
Golay, Xavier;
... Hosford, Patrick S; + view all
(2022)
Cerebral perfusion in untreated, controlled, and uncontrolled hypertension.
Journal of Cerebral Blood Flow and Metabolism
10.1177/0271678x221124644.
(In press).
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Abstract
This study evaluated the association between systemic arterial blood pressure and cerebral perfusion in 740 participants of the UK's largest tri-ethnic study with measurements of cerebral blood flow (CBF) performed using arterial spin labelling MRI. A significant negative correlation between blood pressure, age and CBF was observed across the patient cohort. The lowest CBF values were recorded in the group of patients with hypertension that were prescribed with anti-hypertensive drugs, but uncontrolled on medication. These findings confirm that hypertension is associated with reduced cerebral perfusion and highlight the importance of blood pressure control for the benefit of maintaining brain blood flow.
| Type: | Article |
|---|---|
| Title: | Cerebral perfusion in untreated, controlled, and uncontrolled hypertension |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/0271678x221124644 |
| Publisher version: | https://doi.org/10.1177/0271678X221124644 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10156183 |
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