Zahid, U;
McCutcheon, RA;
Borgan, F;
Jauhar, S;
Pepper, F;
Nour, MM;
Rogdaki, M;
... Howes, OD; + view all
(2022)
The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A {1}^H-MRS study in first-episode psychosis patients.
Frontiers in Psychiatry
, 13
, Article 967941. 10.3389/fpsyt.2022.967941.
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Abstract
INTROODUCTION: Glutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate levels. We investigated the effect of antipsychotic treatment on glutamatergic levels in the anterior cingulate cortex (ACC), and whether there is a relationship between baseline glutamatergic levels and clinical response after antipsychotic treatment in people with first episode psychosis (FEP). MATERIALS AND METHODS: The sample comprised 25 FEP patients; 22 completed magnetic resonance spectroscopy scans at both timepoints. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). RESULTS: There was no significant change in glutamate [baseline 13.23 ± 2.33; follow-up 13.89 ± 1.74; t(21) = −1.158, p = 0.260], or Glx levels [baseline 19.64 ± 3.26; follow-up 19.66 ± 2.65; t(21) = −0.034, p = 0.973]. There was no significant association between glutamate or Glx levels at baseline and the change in PANSS positive (Glu r = 0.061, p = 0.777, Glx r = −0.152, p = 0.477), negative (Glu r = 0.144, p = 0.502, Glx r = 0.052, p = 0.811), general (Glu r = 0.110, p = 0.607, Glx r = −0.212, p = 0.320), or total scores (Glu r = 0.078, p = 0.719 Glx r = −0.155, p = 0.470). CONCLUSION: These findings indicate that treatment response is unlikely to be associated with baseline glutamatergic metabolites prior to antipsychotic treatment, and there is no major effect of antipsychotic treatment on glutamatergic metabolites in the ACC.
| Type: | Article |
|---|---|
| Title: | The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A {1}^H-MRS study in first-episode psychosis patients |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fpsyt.2022.967941 |
| Publisher version: | https://doi.org/10.3389/fpsyt.2022.967941 |
| Language: | English |
| Additional information: | © 2022 Zahid, McCutcheon, Borgan, Jauhar, Pepper, Nour, Rogdaki, Osugo, Murray, Hathway, Murray and Howes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | spectroscopy, NMDA, imaging and schizophrenia, CSF-correction, longitudinal, glutamate |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10155633 |
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