Asadi-Pooya, Ali A;
Patel, Archana A;
Trinka, Eugen;
Mazurkiewicz-Beldzinska, Maria;
Cross, J Helen;
Welty, Timothy E;
(2022)
Recommendations for treatment strategies in people with epilepsy during times of shortage of antiseizure medications.
Epileptic Disorders
, 24
(5)
10.1684/epd.2022.1468.
(In press).
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Abstract
In times of severe antiseizure medication (ASM) shortage due to emergency situations (e.g., disasters, conflicts, sudden disruption to international supply chains), management of people with epilepsy with available ASMs can be difficult. A group of experts was brought together by the International League Against Epilepsy (ILAE) to formulate recommendations for such circumstances. Every effort was made to base these recommendations on direct published literature or extrapolations from basic information available about ASMs. Actual published literature in this area is, however, limited, and at times, assumptions were made by the experts to generate these recommendations. During times of shortage of ASMs, switching between different ASMs (e.g., oxcarbazepine and carbamazepine) can occasionally be considered as a mitigation procedure. However, for many ASMs, the option of an overnight switch to another drug does not exist. Switching from brand to generic or between generic products has often been shown to be safe, if required. Finally, when supplies of benzodiazepines or equipment to administer medications intravenously are not available, rectal administration of some ASMs may be an emergency alternative route for treating serial seizures and status epilepticus. Decision-making with regard to treatment and possible options should be driven by what is best for the patient.
Type: | Article |
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Title: | Recommendations for treatment strategies in people with epilepsy during times of shortage of antiseizure medications |
Location: | France |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1684/epd.2022.1468 |
Publisher version: | https://www.jle.com/10.1684/epd.2022.1468 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Antiseizure, antiepileptic, drug, epilepsy, seizure |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/10155459 |
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