Ampomah, Mary A;
Drake, Jermon A;
Anum, Adote;
Amponsah, Benjamin;
Dei-Adomakoh, Yvonne;
Anie, Kofi;
Mate-Kole, Christopher C;
... Kirkham, Fenella J; + view all
(2022)
A case-control and seven-year longitudinal neurocognitive study of adults with sickle cell disease in Ghana.
British Journal of Haematology
10.1111/bjh.18386.
(In press).
Preview |
Text
A case control and 7 year longitudinal neurocognitive study.pdf - Published Version Download (1MB) | Preview |
Abstract
Ageing in sickle cell disease (SCD) is associated with a myriad of end-organ complications, including cerebrovascular damage and cognitive impairment (CI). Although CI is very common in SCD, little is known about cognitive functioning and how it changes with age. This study examines cognitive patterns of 63 adults with SCD and 60 non-SCD, age- and education-matched controls in Ghana. Of those adults with SCD, 34 completed the neuropsychological battery at baseline and again seven years later. In cross-sectional data, adults with SCD performed worse than controls in all cognitive test domains (p < 0.01 for all). The seven-year follow-up data showed that the group exhibited a significant decline in visuospatial abilities (ranging from Cohen's d = 1.40 to 2.38), and to a lesser extent, in processing speed and executive functioning. Exploratory analyses showed a significant time-by-education interaction, indicating that education may be protective from decline in cognitive performance. These findings have implications for clinical practice. Early neuropsychological surveillance coupled with early assessment and remedial programmes will provide avenues for enhancing the quality of life of adults living with SCD in Ghana.
| Type: | Article |
|---|---|
| Title: | A case-control and seven-year longitudinal neurocognitive study of adults with sickle cell disease in Ghana |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bjh.18386 |
| Publisher version: | https://doi.org/10.1111/bjh.18386 |
| Language: | English |
| Additional information: | © 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | cognitive functioning, longitudinal studies, neurocognitive test, psychology, psychosocial, sickle cell disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10155224 |
Archive Staff Only
 |
View Item |
