Ralph, Elizabeth;
Evans, Josie;
Booth, Claire;
Gilmour, Kimberly;
(2022)
Patients with XLP type 1 have variable numbers of NKT cells.
British Journal of Haematology
, 198
(1)
pp. 151-154.
10.1111/bjh.18159.
Preview |
Text
Gilmour_Patients with XLP type 1 have variable numbers of NKT cells_AAM.pdf Download (214kB) | Preview |
Abstract
X-linked lymphoproliferative disease (XLP1) is a rare primary immunodeficiency that usually presents in early childhood. Patients with XLP1 have been reported to have absent NKT cells, and it has been suggested that this can be diagnostic for the disorder. Whilst NKT frequency in adults is variable, little is known about their frequency in children. Therefore, we established a paediatric reference range for these cells. In contrast to previous reports, in our cohort of XLP1 patients, NKT cell numbers were found to be variable, and we would advise against using the finding of NKT cells to exclude a diagnosis of XLP1.
| Type: | Article |
|---|---|
| Title: | Patients with XLP type 1 have variable numbers of NKT cells |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bjh.18159 |
| Publisher version: | https://doi.org/10.1111/bjh.18159 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | laboratory, lymphoproliferative disease, NKT cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10155064 |
Archive Staff Only
 |
View Item |
