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Time-of-Day Variation in SARS-CoV-2 RNA Levels during the Second Wave of COVID-19

Zhuang, Xiaodong; Wang, Wei; Borrmann, Helene; Balfe, Peter; Matthews, Philippa C; Eyre, David W; Klerman, Elizabeth B; (2022) Time-of-Day Variation in SARS-CoV-2 RNA Levels during the Second Wave of COVID-19. Viruses , 14 (8) , Article 1728. 10.3390/v14081728. Green open access

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Abstract

Circadian rhythms influence and coordinate an organism's response to its environment and to invading pathogens. We studied the diurnal variation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in nasal/throat swabs collected in late 2020 to spring 2021 in a population immunologically naïve to SARS-CoV-2 and prior to widespread vaccination. SARS-CoV-2 diagnostic PCR data from 1698 participants showed a significantly higher viral load in samples obtained in the afternoon, in males, and in hospitalised patients when linear mixed modelling was applied. This study illustrates the importance of recording sample collection times when measuring viral replication parameters in clinical and research studies.

Type: Article
Title: Time-of-Day Variation in SARS-CoV-2 RNA Levels during the Second Wave of COVID-19
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/v14081728
Publisher version: https://doi.org/10.3390/v14081728
Language: English
Additional information: Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Keywords: COVID-19, RNA, SARS-CoV-2, circadian, diurnal
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10154891
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