Fink, Douglas L;
Oladele, David A;
Slack, Abigail J;
Odubela, Oluwatosin;
Musari-Martins, Tomilola;
Okechukwu, Adaobi;
Adetayo, Kemi;
... Salako, Babatunde; + view all
(2022)
A multicentre observational study of HIV, TB and risk of chronic lung disease in urban west Africa.
AIDS
, 36
(14)
pp. 1987-1995.
10.1097/QAD.0000000000003360.
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Abstract
OBJECTIVE: HIV and TB are risk factors for non-communicable chronic lung disease (CLD). Despite the high prevalence of these infections in west Africa, there are no studies that compare CLD between people living with HIV (PLWH) and HIV-negative populations in this setting. This study sought to quantify the contribution of HIV and TB infection in addition to conventional CLD risk factors, such as tobacco and biofuel exposure, to CLD in urban west Africa. DESIGN: A multi-centre cross-sectional study was conducted in three community clinics in Lagos, Nigeria between 2018 and 2019. METHODS: Spirometry, questionnaires and clinical records were used to estimate prevalence of CLD and association with risk factors. RESULTS: 148 HIV-negative individuals and 170 HIV-positive individuals completed the study. Current cigarette (11/318, 3.5%) and lifetime domestic biofuel (6/318, 1.8%) exposures were low. Airway obstruction (33/170, 19.4% vs 12/148, 8.1%, p = 0.004) and CLD (73/170, 42.9% vs 34/148, 23%, p < 0.0001) were more prevalent in PLWH compared to the HIV-negative group. HIV infection (OR 2.35 (1.33, 4.17), p = 0.003) and history of TB (OR 2.09 (1.04, 4.20), p = 0.038) were independently associated with increased risk of CLD. CONCLUSIONS: HIV and TB far outweigh conventional risk factors, including tobacco and domestic biofuel exposure, as drivers of non-communicable CLD in urban west Africa. Current global policy for CLD may have limited impact on CLD in this setting. Enhanced prevention, diagnosis and management strategies for incident HIV and TB infections are likely to have a significant impact on long-term lung health in sub-Saharan Africa (SSA).
| Type: | Article |
|---|---|
| Title: | A multicentre observational study of HIV, TB and risk of chronic lung disease in urban west Africa |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/QAD.0000000000003360 |
| Publisher version: | https://doi.org/10.1097/QAD.0000000000003360 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | HIV, TB, COPD, chronic lung disease, sub-Saharan Africa |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10154583 |
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