Luthra, Shailly;
Orlandi, Marco;
Hussain, Syed Basit;
Leira, Yago;
Botelho, João;
Machado, Vanessa;
Mendes, José João;
... D'Aiuto, Francesco; + view all
(2023)
Treatment of periodontitis and C-reactive protein: A systematic review and meta-analysis of randomized clinical trials.
Journal of Clinical Periodontology
, 50
(1)
pp. 45-60.
10.1111/jcpe.13709.
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Abstract
BACKGROUND: Systemic inflammation is implicated in the onset and progression of several chronic diseases. Periodontitis is a potential trigger of systemic inflammation. PURPOSE: To comprehensively appraise all the evidence on the effects of the treatment of periodontitis on systemic inflammation assessed by serum CRP levels. DATA SOURCES: Six electronic databases were searched up to 10th February 2022 to identify and select articles in English language only. STUDY SELECTION: 26 Randomised controlled clinical trials reporting changes amongst 2579 participants about CRP levels at 6 months or more after treatment. DATA EXTRACTION: Two reviewers independently extracted data and rated the quality of studies. Meta-analyses were performed using random and fixed effect models. RISK OF BIAS: Risk of bias (RoB 2.0 tool) and quality of evidence (GRADEpro GDT tool) analyses were completed. DATA SYNTHESIS: Treatment of periodontitis reduced CRP levels by 0·69mg/L (95% CI: -0.97; -0·40) after six months but limited evidence was retrieved from studies with longer follow-ups. Similar findings were observed in participants with other co-morbidities in addition to periodontitis. Greatest reductions were observed in participants with concentrations of CRP >3 mg/L at baseline. LIMITATIONS: High level of heterogeneity. CONCLUSION: Treatment of periodontitis reduces serum CRP levels (up to six months follow-up) to a degree equivalent to that observed after traditional lifestyle or drug interventions. This evidence supports a causal association between periodontitis and systemic inflammation.
| Type: | Article |
|---|---|
| Title: | Treatment of periodontitis and C-reactive protein: A systematic review and meta-analysis of randomized clinical trials |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jcpe.13709 |
| Publisher version: | https://doi.org/10.1111/jcpe.13709 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | Biomarkers, CRP, Inflammation, Meta-analysis, Periodontitis, Risk factors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10153943 |
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