Herrod, AT; Winter, A; Psoroulas, S; Price, T; Owen, HL; Appleby, RB; Allinson, N; Herrod, AT; Winter, A; Psoroulas, S; Price, T; Owen, HL; Appleby, RB; Allinson, N; Esposito, M; - view fewer (2022) Optimal Configuration of Proton-Therapy Accelerators for Relative-Stopping-Power Resolution in Proton Computed Tomography. Physical Review Applied , 18 (1) , Article 014020. 10.1103/PhysRevApplied.18.014020.

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Abstract

The determination of relative stopping power (RSP) via proton computed tomography (pCT) of a patient is dependent in part on the knowledge of the incoming proton kinetic energies; the uncertainty in these energies is in turn determined by the proton source-Typically a cyclotron. Here, we show that reducing the incident proton beam energy spread may significantly improve RSP determination in pCT. We demonstrate that the reduction of beam energy spread from the typical 1.0% (at 70 MeV) down to 0.2% can be achieved at the proton currents needed for imaging at the Paul Scherrer Institut 250-MeV cyclotron. Through a simulated pCT imaging system, we find that this effect results in RSP resolutions as low as 0.2% for materials such as cortical bone, up to 1% for lung tissue. Several materials offer further improvement when the beam (residual) energy is also chosen such that the detection mechanisms used provide the optimal RSP resolution.

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