Kokebu, DM;
Ahmed, S;
Moodliar, R;
Chiang, C-Y;
Torrea, G;
Van Deun, A;
Goodall, RL;
... Nunn, AJ; + view all
(2022)
Failure or relapse predictors for the STREAM Stage 1 short regimen for RR-TB.
International Journal of Tuberculosis and Lung Disease
, 26
(8)
pp. 753-759.
10.5588/ijtld.22.0073.
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Abstract
BACKGROUND: STREAM (Standardised Treatment Regimens of Anti-tuberculosis drugs for Multidrug-Resistant Tuberculosis) Stage 1 demonstrated non-inferior efficacy of a short regimen for rifampicin-resistant TB (RR-TB) compared to a long regimen as recommended by the WHO. The present paper analyses factors associated with a definite or probable failure or relapse (FoR) event in participants receiving the Short regimen.METHODS: This analysis is restricted to 253 participants allocated to the Short regimen and is based on the protocol-defined modified intention to treat (mITT) population. Multivariable Cox regression models were built using backwards elimination with an exit probability of P = 0.157, equivalent to the Akaike Information Criterion, to identify factors independently associated with a definite or probable FoR event.RESULTS: Four baseline factors were identified as being significantly associated with the risk of definite or probable FoR (male sex, a heavily positive baseline smear grade, HIV co-infection and the presence of costophrenic obliteration). There was evidence of association of culture positivity at Week 8 and FoR in a second model and Week 16 smear positivity, presence of diabetes and of smoking in a third model.CONCLUSION: The factors associated with FoR outcomes identified in this analysis should be considered when determining the optimal shortened treatment regimen.
| Type: | Article |
|---|---|
| Title: | Failure or relapse predictors for the STREAM Stage 1 short regimen for RR-TB |
| Location: | France |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.5588/ijtld.22.0073 |
| Publisher version: | https://doi.org/10.5588/ijtld.22.0073 |
| Language: | English |
| Additional information: | This article is Open Access under the terms of the Creative Commons CC BY licence (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | factors predicting treatment outcome; failure or relapse; rifampicin-resistant tuberculosis; short regimen |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10153224 |
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