Wheatcroft, Thomas;
Saleem, Aman B;
Solomon, Samuel G;
(2022)
Functional Organisation of the Mouse Superior Colliculus.
Frontiers in Neural Circuits
, 16
, Article 792959. 10.3389/fncir.2022.792959.
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Abstract
The superior colliculus (SC) is a highly conserved area of the mammalian midbrain that is widely implicated in the organisation and control of behaviour. SC receives input from a large number of brain areas, and provides outputs to a large number of areas. The convergence and divergence of anatomical connections with different areas and systems provides challenges for understanding how SC contributes to behaviour. Recent work in mouse has provided large anatomical datasets, and a wealth of new data from experiments that identify and manipulate different cells within SC, and their inputs and outputs, during simple behaviours. These data offer an opportunity to better understand the roles that SC plays in these behaviours. However, some of the observations appear, at first sight, to be contradictory. Here we review this recent work and hypothesise a simple framework which can capture the observations, that requires only a small change to previous models. Specifically, the functional organisation of SC can be explained by supposing that three largely distinct circuits support three largely distinct classes of simple behaviours–arrest, turning towards, and the triggering of escape or capture. These behaviours are hypothesised to be supported by the optic, intermediate and deep layers, respectively.
| Type: | Article |
|---|---|
| Title: | Functional Organisation of the Mouse Superior Colliculus |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fncir.2022.792959 |
| Publisher version: | https://doi.org/10.3389/fncir.2022.792959 |
| Language: | English |
| Additional information: | Copyright © 2022 Wheatcroft, Saleem and Solomon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, mouse vision, instinctive behaviour, midbrain, threat, approach, sensorimotor, DEFENSIVE RESPONSES, MIDBRAIN CIRCUITS, LOCOMOTOR SPEED, MOTOR CONTROL, BEHAVIOR, NEURONS, DECISION, NUCLEUS, MICE, FEAR |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10152477 |
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