Wangkumhang, Pongsakorn; Greenfield, Matthew; Hellenthal, Garrett; (2022) An efficient method to identify, date, and describe admixture events using haplotype information. Genome Research 10.1101/gr.275994.121. (In press).

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Abstract

We present fastGLOBETROTTER, an efficient new haplotype-based technique to identify, date, and describe admixture events using genome-wide autosomal data. With simulations, we demonstrate how fastGLOBETROTTER reduces computation time by an order of magnitude relative to the related technique GLOBETROTTER without suffering loss of accuracy. We apply fastGLOBETROTTER to a cohort of >6000 Europeans from ten countries, revealing previously unreported admixture signals. In particular we infer multiple periods of admixture related to East Asian or Siberian-like sources, starting >2000 years ago, in people living in countries north of the Baltic Sea. In contrast, we infer admixture related to West Asian, North African and/or Southern European sources in populations south of the Baltic Sea, including admixture dated to ≈300-700CE, overlapping the fall of the Roman Empire, in people from Belgium, France and parts of Germany. Our new approach scales to analyzing hundreds to thousands of individuals from a putatively admixed population and hence is applicable to emerging large-scale cohorts of genetically homogeneous populations.

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