Breast cancer worry in higher-risk women offered preventive therapy: a UK multicentre prospective study

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Breast cancer worry in higher-risk women offered preventive therapy: a UK multicentre prospective study

Lloyd, Kelly E; Hall, Louise H; Ziegler, Lucy; Smith, Samuel G; (2021) Breast cancer worry in higher-risk women offered preventive therapy: a UK multicentre prospective study. Breast Cancer Research and Treatment , 188 (3) pp. 703-712. 10.1007/s10549-021-06183-x. Green open access

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Abstract

PURPOSE: Women's worry about developing breast cancer may influence their decision to use preventive therapy. However, the direction of this relationship has been questioned. We prospectively investigated the relationship between breast cancer worry and uptake of preventive therapy. The socio-demographic and clinical factors associated with high breast cancer worry were also investigated. METHODS: Women at increased risk of developing breast cancer were recruited from clinics across England (n = 408). Participants completed a survey on their breast cancer worry, socio-demographic and clinical factors. Uptake of tamoxifen was recorded at 3 months (n = 258 women, 63.2%). Both primary and sensitivity analyses were conducted using different classifications of low, medium and high worry. RESULTS: 39.5% of respondents reported medium breast cancer worry at baseline and 21.2% reported high worry. Ethnic minority women were more likely to report high worry than white women (OR = 3.02, 95%CI 1.02, 8.91, p = 0.046). Women educated below degree level were more likely to report high worry than those with higher education (OR = 2.29, 95%CI 1.28, 4.09, p = 0.005). No statistically significant association was observed between worry and uptake. In the primary analysis, fewer respondents with medium worry at baseline initiated tamoxifen (low worry = 15.5%, medium = 13.5%, high = 15.7%). In the sensitivity analysis, participants with medium worry reported the highest uptake of tamoxifen (19.7%). CONCLUSIONS: No association was observed between worry and uptake, although the relationship was affected by the categorisation of worry. Standardised reporting of the classification of worry is warranted to allow transparent comparisons across cohorts.

Type:	Article
Title:	Breast cancer worry in higher-risk women offered preventive therapy: a UK multicentre prospective study
Location:	Netherlands
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1007/s10549-021-06183-x
Publisher version:	https://doi.org/10.1007/s10549-021-06183-x
Language:	English
Additional information:	This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords:	Science & Technology, Life Sciences & Biomedicine, Oncology, Preventive therapy, Chemoprevention, Decision-making, Cancer worry
UCL classification:	UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI:	https://discovery.ucl.ac.uk/id/eprint/10152023