Cengiz, Bülent;
Boran, H Evren;
Alaydın, Halil Can;
Tankisi, Hatice;
Samusyte, Gintaute;
Howells, James;
Koltzenburg, Martin;
(2022)
Short latency afferent inhibition: comparison between threshold-tracking and conventional amplitude recording methods.
Experimental Brain Research
, 240
(4)
pp. 1241-1247.
10.1007/s00221-022-06327-5.
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Abstract
Short-latency afferent inhibition (SAI), which is conventionally measured as a reduction in motor evoked potential amplitude (A-SAI), is of clinical interest as a potential biomarker for cognitive impairment. Since threshold-tracking has some advantages for clinical studies of short-interval cortical inhibition, we have compared A-SAI with a threshold-tracking alternative method (T-SAI). In the T-SAI method, inhibition was calculated by tracking the required TMS intensity for the targeted MEP amplitude (200 uV) both for the test (TMS only) and paired (TMS and peripheral stimulation) stimuli. A-SAI and T-SAI were recorded from 31 healthy subjects using ten stimuli at each of 12 inter-stimulus intervals, once in the morning and again in the afternoon. There were no differences between morning and afternoon recordings. When A-SAI was normalized by log conversion it was closely related to T-SAI. Between subjects, variability was similar for the two techniques, but within-subject variability was significantly smaller for normalized A-SAI. Conventional amplitude measurements appear more sensitive for detecting changes within-subjects, such as in interventional studies, but threshold-tracking may be as sensitive as detecting abnormal SAI in a patient.
| Type: | Article |
|---|---|
| Title: | Short latency afferent inhibition: comparison between threshold-tracking and conventional amplitude recording methods |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00221-022-06327-5 |
| Publisher version: | https://doi.org/10.1007/s00221-022-06327-5 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Short latency afferent inhibition, Amplitude measurement, Threshold-tracking, Variability, TRANSCRANIAL MAGNETIC STIMULATION, INTERVAL INTRACORTICAL INHIBITION, MOTOR CORTEX, PLASTICITY |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10151975 |
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