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Short latency afferent inhibition: comparison between threshold-tracking and conventional amplitude recording methods

Cengiz, Bülent; Boran, H Evren; Alaydın, Halil Can; Tankisi, Hatice; Samusyte, Gintaute; Howells, James; Koltzenburg, Martin; (2022) Short latency afferent inhibition: comparison between threshold-tracking and conventional amplitude recording methods. Experimental Brain Research , 240 (4) pp. 1241-1247. 10.1007/s00221-022-06327-5. Green open access

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Abstract

Short-latency afferent inhibition (SAI), which is conventionally measured as a reduction in motor evoked potential amplitude (A-SAI), is of clinical interest as a potential biomarker for cognitive impairment. Since threshold-tracking has some advantages for clinical studies of short-interval cortical inhibition, we have compared A-SAI with a threshold-tracking alternative method (T-SAI). In the T-SAI method, inhibition was calculated by tracking the required TMS intensity for the targeted MEP amplitude (200 uV) both for the test (TMS only) and paired (TMS and peripheral stimulation) stimuli. A-SAI and T-SAI were recorded from 31 healthy subjects using ten stimuli at each of 12 inter-stimulus intervals, once in the morning and again in the afternoon. There were no differences between morning and afternoon recordings. When A-SAI was normalized by log conversion it was closely related to T-SAI. Between subjects, variability was similar for the two techniques, but within-subject variability was significantly smaller for normalized A-SAI. Conventional amplitude measurements appear more sensitive for detecting changes within-subjects, such as in interventional studies, but threshold-tracking may be as sensitive as detecting abnormal SAI in a patient.

Type: Article
Title: Short latency afferent inhibition: comparison between threshold-tracking and conventional amplitude recording methods
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00221-022-06327-5
Publisher version: https://doi.org/10.1007/s00221-022-06327-5
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Short latency afferent inhibition, Amplitude measurement, Threshold-tracking, Variability, TRANSCRANIAL MAGNETIC STIMULATION, INTERVAL INTRACORTICAL INHIBITION, MOTOR CORTEX, PLASTICITY
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10151975
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