Bruno, Davide;
Jauregi Zinkunegi, Ainara;
Pomara, Nunzio;
Zetterberg, Henrik;
Blennow, Kaj;
Koscik, Rebecca Langhough;
Carlsson, Cynthia;
... Mueller, Kimberly D; + view all
(2022)
Cross-sectional associations of CSF tau levels with Rey's AVLT: A recency ratio study.
Neuropsychology
10.1037/neu0000821.
(In press).
Preview |
Text
Zetterberg_Bruno.pdf Download (286kB) | Preview |
Abstract
OBJECTIVE: The preeminent in vivo cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are amyloid β 1-42 (Aβ42), phosphorylated Tau (p-tau), and total Tau (t-tau). The goal of this study was to examine how well traditional (total and delayed recall) and process-based (recency ratio [Rr]) measures derived from Rey's Auditory Verbal Learning test (AVLT) were associated with these biomarkers. METHOD: Data from 235 participants (Mage = 65.5, SD = 6.9), who ranged from cognitively unimpaired to mild cognitive impairment, and for whom CSF values were available, were extracted from the Wisconsin Registry for Alzheimer's Prevention. Bayesian regression analyses were carried out using CSF scores as outcomes, AVLT scores as predictors, and controlling for demographic data and diagnosis. RESULTS: We found moderate evidence that Rr was associated with both CSF p-tau (Bayesian factor [BFM] = 5.55) and t-tau (BFM = 7.28), above and beyond the control variables, while it did not correlate with CSF Aβ42 levels. In contrast, total and delayed recall scores were not linked with any of the AD biomarkers, in separate analyses. When comparing all memory predictors in a single regression, Rr remained the strongest predictor of CSF t-tau levels (BFM = 3.57). CONCLUSIONS: Our findings suggest that Rr may be a better cognitive measure than commonly used AVLT scores to assess CSF levels of p-tau and t-tau in nondemented individuals. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
| Type: | Article |
|---|---|
| Title: | Cross-sectional associations of CSF tau levels with Rey's AVLT: A recency ratio study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1037/neu0000821 |
| Publisher version: | https://psycnet.apa.org/doi/10.1037/neu0000821 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Social Sciences, Science & Technology, Life Sciences & Biomedicine, Psychology, Clinical, Neurosciences, Psychology, Neurosciences & Neurology, A/T/N biomarkers, Alzheimer's disease, CSF tau, CSF A beta 42, recency ratio, MILD COGNITIVE IMPAIRMENT, WHITE-MATTER HYPERINTENSITY, ALZHEIMERS-DISEASE, AFRICAN-AMERICANS, DIAGNOSTIC GUIDELINES, WISCONSIN-REGISTRY, NATIONAL INSTITUTE, RECALL, RECOMMENDATIONS, PERFORMANCE |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10150818 |
Archive Staff Only
 |
View Item |
