Kasaven, Lorraine S;
Saso, Srdjan;
Getreu, Natalie;
O’Neill, Helen;
Bracewell-Milnes, Timothy;
Shakir, Fevzi;
Yazbek, Joseph;
... Jones, Benjamin P; + view all
(2022)
Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation?
Human Reproduction
, Article deac144. 10.1093/humrep/deac144.
(In press).
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Abstract
Age-related fertility decline (ARFD) is a prevalent concern amongst western cultures due to the increasing age of first-time motherhood. Elective oocyte and embryo cryopreservation remain the most established methods of fertility preservation, providing women the opportunity of reproductive autonomy to preserve their fertility and extend their childbearing years to prevent involuntary childlessness. Whilst ovarian cortex cryopreservation has been used to preserve reproductive potential in women for medical reasons, such as in pre- or peripubertal girls undergoing gonadotoxic chemotherapy, it has not yet been considered in the context of ARFD. As artificial reproductive technology (ART) and surgical methods of fertility preservation continue to evolve, it is a judicious time to review current evidence and consider alternative options for women wishing to delay their fertility. This article critically appraises elective oocyte cryopreservation as an option for women who use it to mitigate the risk of ARFD and introduces the prospect of elective ovarian cortex cryopreservation as an alternative.
| Type: | Article |
|---|---|
| Title: | Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/humrep/deac144 |
| Publisher version: | https://doi.org/10.1093/humrep/deac144 |
| Language: | English |
| Additional information: | © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| Keywords: | age-related fertility decline / elective oocyte cryopreservation / ovarian tissue cryopreservation / fertility preservation / vitrification |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10150769 |
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