Geiller, Tristan;
Sadeh, Sadra;
Rolotti, Sebastian;
Blockus, Heike;
Vancura, Bert;
Negrean, Adrian;
Murray, Andrew J;
... Losonczy, Attila; + view all
(2022)
Local circuit amplification of spatial selectivity in the hippocampus.
Nature
, 601
(7891)
pp. 105-109.
10.1038/s41586-021-04169-9.
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Abstract
Local circuit architecture facilitates the emergence of feature selectivity in the cerebral cortex1. In the hippocampus, it remains unknown whether local computations supported by specific connectivity motifs2 regulate the spatial receptive fields of pyramidal cells3. Here we developed an in vivo electroporation method for monosynaptic retrograde tracing4 and optogenetics manipulation at single-cell resolution to interrogate the dynamic interaction of place cells with their microcircuitry during navigation. We found a local circuit mechanism in CA1 whereby the spatial tuning of an individual place cell can propagate to a functionally recurrent subnetwork5 to which it belongs. The emergence of place fields in individual neurons led to the development of inverse selectivity in a subset of their presynaptic interneurons, and recruited functionally coupled place cells at that location. Thus, the spatial selectivity of single CA1 neurons is amplified through local circuit plasticity to enable effective multi-neuronal representations that can flexibly scale environmental features locally without degrading the feedforward input structure.
| Type: | Article |
|---|---|
| Title: | Local circuit amplification of spatial selectivity in the hippocampus |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41586-021-04169-9 |
| Publisher version: | https://doi.org/10.1038/s41586-021-04169-9 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, FUNCTIONAL-ORGANIZATION, SYNAPTIC PLASTICITY, CA1 PLACE, NETWORK |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10150730 |
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