Mathew, Boby;
Hauptmann, Andreas;
Leon, Jens;
Sillanpaeae, Mikko J;
(2022)
NeuralLasso: Neural Networks Meet Lasso in Genomic Prediction.
Frontiers in Plant Science
, 13
, Article 800161. 10.3389/fpls.2022.800161.
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Abstract
Prediction of complex traits based on genome-wide marker information is of central importance for both animal and plant breeding. Numerous models have been proposed for the prediction of complex traits and still considerable effort has been given to improve the prediction accuracy of these models, because various genetics factors like additive, dominance and epistasis effects can influence of the prediction accuracy of such models. Recently machine learning (ML) methods have been widely applied for prediction in both animal and plant breeding programs. In this study, we propose a new algorithm for genomic prediction which is based on neural networks, but incorporates classical elements of LASSO. Our new method is able to account for the local epistasis (higher order interaction between the neighboring markers) in the prediction. We compare the prediction accuracy of our new method with the most commonly used prediction methods, such as BayesA, BayesB, Bayesian Lasso (BL), genomic BLUP and Elastic Net (EN) using the heterogenous stock mouse and rice field data sets.
| Type: | Article |
|---|---|
| Title: | NeuralLasso: Neural Networks Meet Lasso in Genomic Prediction |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fpls.2022.800161 |
| Publisher version: | https://doi.org/10.3389/fpls.2022.800161 |
| Language: | English |
| Additional information: | © 2022 Mathew, Hauptmann, Léon and Sillanpää. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Neural networks, LASSO, local epistasis, genomic selection, whole genome prediction |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10149894 |
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