McMurran, Christopher E;
Mukherjee, Trisha;
Brown, J William L;
Michell, Andrew W;
Chard, Declan T;
Franklin, Robin JM;
Coles, Alasdair J;
(2022)
Remyelination in humans due to a retinoid-X receptor agonist is age-dependent.
Annals of Clinical and Translational Neurology
, 9
(7)
pp. 1090-1094.
10.1002/acn3.51595.
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Abstract
Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that bexarotene, a putatively remyelinating retinoid-X receptor agonist, shortened the visual evoked potential latency in patients with chronic optic neuropathy aged under 42 years only (with the effect diminishing by 0.45 ms per year of age); and increased the magnetization transfer ratio of deep gray matter lesions in those under 43 years only. Addressing this age-related decline in human remyelination capacity will be an important step in the development of remyelinating therapies that work across the lifespan.
| Type: | Article |
|---|---|
| Title: | Remyelination in humans due to a retinoid-X receptor agonist is age-dependent |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/acn3.51595 |
| Publisher version: | https://doi.org/10.1002/acn3.51595 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10149828 |
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