Sveijer, Malin;
Von Bahr Greenwood, Tatiana;
Jädersten, Martin;
Kvedaraite, Egle;
Zetterberg, Henrik;
Blennow, Kaj;
Lourda, Magda;
... Henter, Jan-Inge; + view all
(2022)
Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma.
British Journal of Haematology
10.1111/bjh.18247.
(In press).
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Abstract
Patients with Langerhans cell histiocytosis (LCH) may develop progressive neurodegeneration in the central nervous system (ND-CNS-LCH). Neurofilament light protein (NFL) in cerebrospinal fluid (CSF) is a promising biomarker to detect and monitor ND-CNS-LCH. We compared paired samples of NFL in plasma (p-NFL) and CSF in 10 patients (19 samples). Nine samples had abnormal CSF-NFL (defined as ≥380 ng/l) with corresponding p-NFL ≥ 2 ng/l. Ten samples had CSF-NFL < 380 ng/l; eight (80%) with p-NFL < 2 ng/l (p < 0.001; Fisher's exact test). Thus, our results suggest that p-NFL may be used to screen for ND-CNS-LCH. Further studies are encouraged, including the role of p-NFL for monitoring of ND-CNS-LCH.
| Type: | Article |
|---|---|
| Title: | Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bjh.18247 |
| Publisher version: | https://doi.org/10.1111/bjh.18247 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | Langerhans cell histiocytosis, central nervous system (CNS), neurodegeneration, neurofilament light chain protein (NFL) |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10149465 |
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