Karan, Sanu;
Cho, Mi Young;
Lee, Hyunseung;
Park, Hye Sun;
Han, Eun Hee;
Song, Youngkyu;
Lee, Youlee;
... Hong, Kwan Soo; + view all
(2022)
Hypoxia-Responsive Luminescent CEST MRI Agent for In Vitro and In Vivo Tumor Detection and Imaging.
Journal of Medicinal Chemistry
, 65
(10)
pp. 7106-7117.
10.1021/acs.jmedchem.1c01745.
Preview |
Text (Accepted manuscript)
revised manuscript_JMC_20220427_final.pdf - Accepted Version Download (1MB) | Preview |
Preview |
Text (Supplementary material)
jm1c01745_si_001.pdf - Supplemental Material Download (1MB) | Preview |
Abstract
Hypoxia is a feature of most solid tumors and a key determinant of cancer growth and propagation. Sensing hypoxia effectively could lead to more favorable clinical outcomes. Here, we report a molecular antenna-based bimodal probe designed to exploit the complementary advantages of magnetic resonance (MR)- and optical-based imaging. Specifically, we describe the synthesis and evaluation of a dual-action probe (NO2-Eu) that permits hypoxia-activated chemical exchange saturation transfer (CEST) MR and optical imaging. In CT26 cells, this NO2-Eu probe not only provides an enhanced CEST MRI signal but also turns “on” the optical signal under hypoxic conditions. Time-dependent in vivo CEST imaging in a hypoxic CT26 tumor xenograft mouse model revealed probe-dependent tumor detection by CEST MRI contrast in the tumor area. We thus suggest that dual-action hypoxia probes, like that reported here, could have a role to play in solid tumor diagnosis and monitoring.
| Type: | Article |
|---|---|
| Title: | Hypoxia-Responsive Luminescent CEST MRI Agent for In Vitro and In Vivo Tumor Detection and Imaging |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.jmedchem.1c01745 |
| Publisher version: | https://doi.org/10.1021/acs.jmedchem.1c01745 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10149370 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
