Phakoukaki, Yiota-Victoria;
O'Shaughnessy, Paul;
Angeli, Panagiota;
(2022)
Intensified liquid-liquid extraction of biomolecules using ionic liquids in small channels.
Separation and Purification Technology
, 282
(Part B)
, Article 120063. 10.1016/j.seppur.2021.120063.
Preview |
Text
AminoAcid_SPTech_Final-Rev.pdf - Accepted Version Download (1MB) | Preview |
Abstract
The continuous extraction of an amino acid from an aqueous solution into an ionic liquid phase was studied experimentally in small channels, demonstrating a double intensification of the solvent used and the overall process. Channels with 0.5, 1 and 2 mm internal diameter were used for the extraction of the amino acid, L-tryptophan from an aqueous solution (0.005 mol L−1), into a hydrophobic ionic liquid, 1-Butyl-3-methylimidazolium Bis (trifluoromethanesulfonyl)imide, [C4mim][Tf2N] in the presence of a crown ether extractant, Dicyclohexano-18-crown-6, (DC18C6). A mechanism was proposed for the extraction which involved the ammonium centre of the amino acid forming hydrogen bonds with the 18-crown-6 part of the extractant at a 1:1 ratio. Partition coefficients up to 25 were obtained. The continuous extraction experiments were carried out during plug flow where the interfacial areas reported reached up to 5500 m2m−3 at 50% volume fractions. Extraction efficiencies up to 90% were obtained for residence times less than 30 s. Overall mass transfer coefficients (KLα) found reached up to 0.14 s−1.
| Type: | Article |
|---|---|
| Title: | Intensified liquid-liquid extraction of biomolecules using ionic liquids in small channels |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.seppur.2021.120063 |
| Publisher version: | https://doi.org/10.1016/j.seppur.2021.120063 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Technology, Engineering, Chemical, Engineering, Liquid-liquid, Plug flow, Extraction, Ionic liquid, Biomolecules, MASS-TRANSFER, AMINO-ACIDS, SLUG FLOW, SOLVENT-EXTRACTION, MICROFLUIDIC DEVICES, MEDIATED EXTRACTION, CROWN-ETHERS, TAYLOR FLOW, PLUG-FLOW, HYDRODYNAMICS |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10148663 |
Archive Staff Only
 |
View Item |
