Lorincz, Balazs;
Jury, Elizabeth C;
Vrablik, Michal;
Ramanathan, Murali;
Uher, Tomas;
(2022)
The role of cholesterol metabolism in multiple sclerosis: From molecular pathophysiology to radiological and clinical disease activity.
Autoimmunity Reviews
, 21
(6)
, Article 103088. 10.1016/j.autrev.2022.103088.
Preview |
Text (Article)
Cholesterol and MS minireview accepted.pdf - Accepted Version Download (301kB) | Preview |
![[thumbnail of Figure 1]](https://discovery.ucl.ac.uk/10147181/3/Cholesterol%20metab.%20in%20brain%20-%20Figure%201.jpeg)  Preview |
Text (Figure 1)
Cholesterol metab. in brain - Figure 1.jpeg - Accepted Version Download (1MB) | Preview |
![[thumbnail of Figure 2]](https://discovery.ucl.ac.uk/10147181/2/Lipidogram%20vs.%20MRI%20review%20chart%20-%20Figure%202.png)  Preview |
Text (Figure 2)
Lipidogram vs. MRI review chart - Figure 2.png - Accepted Version Download (514kB) | Preview |
Abstract
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS leading to demyelination and axonal degeneration. An increasing body of evidence suggests that lipid metabolism is associated with adverse clinical and MRI outcomes in MS. In this review we summarize the findings of association between low-density lipoproteins (LDL), high-density lipoproteins (HDL), their apolipoproteins and oxysterols with clinical and radiological disease activity in MS. Although the causality between disease activity in MS and abnormalities in lipid metabolism has not yet been elucidated, we suggest that advances in this field of research have the potential to improve understanding of MS pathophysiology and the identification of new treatment targets and strategies.
| Type: | Article |
|---|---|
| Title: | The role of cholesterol metabolism in multiple sclerosis: From molecular pathophysiology to radiological and clinical disease activity |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.autrev.2022.103088 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | HDL, LDL, LXR, MRI, multiple sclerosis, Oxysterols |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10147181 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
