Ayoubkhani, Daniel;
Bermingham, Charlotte;
Pouwels, Koen B;
Glickman, Myer;
Nafilyan, Vahe;
Zaccardi, Francesco;
Khunti, Kamlesh;
... Walker, Ann; + view all
(2022)
Changes in the trajectory of Long Covid symptoms following COVID-19 vaccination: community-based cohort study.
BMJ: British Medical Journal
(In press).
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Abstract
OBJECTIVE: To estimate associations between COVID-19 vaccination and Long Covid symptoms in adults who were infected with SARS-CoV-2 prior to vaccination. DESIGN: Observational cohort study using individual-level interrupted time series analysis. SETTING: Random sample from the community population of the UK. PARTICIPANTS: 28,356 COVID-19 Infection Survey participants (mean age 46 years, 56% female, 89% white) aged 18 to 69 years who received at least their first vaccination after test-confirmed infection. MAIN OUTCOME MEASURES: Presence of Long Covid symptoms at least 12 weeks after infection over the follow-up period 3 February to 5 September 2021. RESULTS: Median follow-up was 141 days from first vaccination (among all participants) and 67 days from second vaccination (84% of participants). First vaccination was associated with an initial 12.8% decrease (95% confidence interval: -18.6% to -6.6%, p<0.001) in the odds of Long Covid, with the data being compatible with both increases and decreases in the trajectory (+0.3% per week, 95% CI: -0.6% to +1.2% per week, p=0.51) after this. Second vaccination was associated with an 8.8% decrease (95% CI: -14.1% to -3.1%, p=0.003) in the odds of Long Covid, with the odds subsequently decreasing by 0.8% (-1.2% to -0.4%, p<0.001) per week. There was no statistical evidence of heterogeneity in associations between vaccination and Long Covid by socio-demographic characteristics, health status, whether hospitalised with acute COVID-19, vaccine type (adenovirus vector or mRNA), or duration from infection to vaccination. CONCLUSIONS: : The likelihood of Long Covid symptoms reduced after COVID-19 vaccination, and there was evidence of a sustained improvement after the second dose, at least over the median follow-up time of 67 days. Vaccination may contribute to a reduction in the population health burden of Long Covid, though longer follow-up time is needed.
| Type: | Article |
|---|---|
| Title: | Changes in the trajectory of Long Covid symptoms following COVID-19 vaccination: community-based cohort study |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://www.bmj.com/ |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10146829 |
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