Petzold, Axel; (2022) Lady Estelle Wolfson Lecture 2022: Neurofilaments. Presented at: Medicine 2022, London, UK.

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Abstract

Dr Axel Petzold works as consultant neurologist at the National Hospital for Neurology and Neurosurgery, Moorfields Eye Hospital and the Amsterdam University Medical Centre. His interest in translational medicine originated in the challenge to timely quantify what is prognostically relevant for any human afflicted by disease: neurodegeneration. Neurological loss of function is related to loss of neurons and axons. The late consequence – atrophy – can be demonstrated by imaging, but this is too late to influence the disease course. Therefore, Dr Petzold pioneered analytical methods which permit reliable quantification of compounds released during the acute phase of neurodegeneration. He contributed to analytical, experimental and clinical validation. These methods are now in their 4th generation and used successfully as outcome measures in treatment trials. In his Lady Estelle Wolfson Lectureship, he will speak about neurofilaments, starting with a 2,600-year-old murder mystery.

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