Lewis, S;
Barry, A;
Hawkins, MA;
(2022)
Hypofractionation in Hepatocellular Carcinoma – The Effect of Fractionation Size.
Clinical Oncology
, 34
(5)
e195-e209.
10.1016/j.clon.2022.02.021.
Preview |
Text
Hawkins_1-s2.0-S0936655522001054-main.pdf Download (1MB) | Preview |
Abstract
The use of stereotactic body radiotherapy (SBRT) in hepatocellular carcinoma (HCC) has increased over the years. Several prospective studies have demonstrated its safety and efficacy, and randomised trials are underway. The advancement in technology has enabled the transition from three-dimensional conformal radiotherapy to highly focused SBRT. Liver damage is the primary limiting toxicity with radiation, with the incidence of grade 3 varying from 0 to 30%. The reported radiotherapy fractionation schedule for HCC, and in practice use, ranges from one to 10 fractions, based on clinician preference and technology available, tumour location and tumour size. This review summarises the safety and efficacy of various SBRT fractionation schedules for HCC.
| Type: | Article |
|---|---|
| Title: | Hypofractionation in Hepatocellular Carcinoma – The Effect of Fractionation Size |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clon.2022.02.021 |
| Publisher version: | https://doi.org/10.1016/j.clon.2022.02.021 |
| Language: | English |
| Additional information: | © 2022 The Authors. Published by Elsevier Ltd on behalf of The Royal College of Radiologists. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Dose fractionation, External beam radiotherapy (EBRT), Hepatocellular carcinoma (HCC), Hypofractionation, Radiotherapy, Stereotactic body radiotherapy (SBRT) |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10146369 |
Archive Staff Only
 |
View Item |
