Strawson, Will H; Wang, Hao-Ting; Quadt, Lisa; Sherman, Maxine; Larsson, Dennis EO; Davies, Geoff; Mckeown, Bronte LA; ... Garfinkel, Sarah N; + view all Strawson, Will H; Wang, Hao-Ting; Quadt, Lisa; Sherman, Maxine; Larsson, Dennis EO; Davies, Geoff; Mckeown, Bronte LA; Silva, Marta; Fielding-Smith, Sarah; Jones, Anna-Marie; Hayward, Mark; Smallwood, Jonathan; Critchley, Hugo D; Garfinkel, Sarah N; - view fewer (2021) Voice Hearing in Borderline Personality Disorder Across Perceptual, Subjective, and Neural Dimensions. International Journal of Neuropsychopharmacology 10.1093/ijnp/pyab093. (In press).

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Abstract

BACKGROUND: Auditory verbal hallucinations (AVH) commonly occur in the context of borderline personality disorder (BPD) yet remain poorly understood. AVH are often perceived by patients with BPD as originating from inside the head and hence viewed clinically as 'pseudohallucinations', but they nevertheless have a detrimental impact on wellbeing. METHODS: The current study characterised perceptual, subjective and neural expressions of AVH by using an auditory detection task, experience sampling and questionnaires, and functional neuroimaging respectively. RESULTS: Perceptually, reported AVH correlated with a bias for reporting the presence of a voice in white noise. Subjectively, questionnaire measures indicated that AVH were significantly distressing and persecutory. In addition, AVH intensity, but not perceived origin (i.e. inside vs. outside the head), was associated with greater concurrent anxiety. Neurally, fMRI of BPD participants demonstrated that, relative to imagining or listening to voices, periods of reported AVH induced greater BOLD activity in anterior cingulate and bilateral temporal cortices (regional substrates for language processing). AVH symptom severity was associated with weaker functional connectivity between anterior cingulate and bilateral insular cortices. CONCLUSION: In summary, our results indicate that AVH in participants with BPD are; 1) underpinned by aberrant perceptual-cognitive mechanisms for signal detection; 2) experienced subjectively as persecutory and distressing, and; 3) associated with distinct patterns of neural activity that inform proximal mechanistic understanding. Our findings are similar to analogous observations in patients with schizophrenia and validate the clinical significance of the AVH experience in BPD, often dismissed as 'pseudohallucinations'. These highlight a need to reconsider this experience as a treatment priority.

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