Street, James Spencer;
(2022)
Cortical contributions to landmark integration in the rodent head direction system.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
Head direction (HD) cells in the rodent brain can use visual information about surrounding landmarks to ‘reset’ their represented orientation, to keep it aligned with the world (a process called landmark anchoring). This implies HD cells receive input from the visual system about the surrounding panorama and its landmarks. Which features in a panorama are used by the HD system? Can HD cells integrate raw luminance input from across the panorama, as might be subserved by subcortical visual processing? Alternatively, do HD cells need discretised landmarks with features, requiring more elaborate visual landmark processing and recognition? I present work addressing how visual information reaches the HD circuit in rats. In the first experiment, we ask whether HD cells require discrete landmarks to anchor to visual panoramas. We record HD cells in a landmark anchoring paradigm using a visual panorama containing a single gradient shifting gradually from black to grey to black. Although there was evidence HD cells could integrate information from this scene, cue control was weak and less reliable than anchoring to visual landmarks with edges. In the second experiment, I present HD cell recordings in rats with lesions of the lateral geniculate nucleus, the thalamic relay of the cortical visual pathway, to test whether subcortical vision is sufficient for landmark-anchoring. HD cells in these animals showed impaired anchoring to cue cards, and lesion extent correlated with the severity of the impairment. Together, these findings indicate that the cortical visual pathway is necessary for intact and stable landmark anchoring to visual cues. Although this process can use entire visual panoramas, it may be more precise if distinct features are available in the scene. Landmark processing in the brain may be complex, and further work could probe whether direct projections from visual cortex provide this information to the HD circuit.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Cortical contributions to landmark integration in the rodent head direction system |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2022. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10145842 |
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