Abdel-Mannan, Omar;
Mankad, Kishitij;
Be-Sira, Liat;
Uliel-Sibony, Shimrit;
Hacohen, Yael;
Meirson, Hadas;
(2022)
Should epileptic seizures as a first presentation be considered part of diagnostic criteria for relapsing remitting multiple sclerosis?
Neuroimmunology Reports
, 2
, Article 100086. 10.1016/j.nerep.2022.100086.
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Abstract
We report two children who presented with seizures prior to Multiple Sclerosis (MS) diagnosis. A 12-year-old female presented in status epilepticus with periventricular white matter lesions on MRI. Eleven months later, she had a severe clinical relapse fulfilling MS diagnostic criteria. A 14-year-old male, was found on neuroimaging for cholesteatoma to have multiple cortical and subcortical T2 lesions, with a focal-onset seizure 1-year later. Serial neuroimaging showed new lesions. Oligoclonal bands were positive for both patients. Epileptic seizures can be the first presentation in pediatric MS patients prior to typical demyelination symptoms, with potential for inclusion in future diagnostic criteria.
| Type: | Article |
|---|---|
| Title: | Should epileptic seizures as a first presentation be considered part of diagnostic criteria for relapsing remitting multiple sclerosis? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.nerep.2022.100086 |
| Publisher version: | https://doi.org/10.1016/j.nerep.2022.100086 |
| Language: | English |
| Additional information: | © 2022 The Author(s). Published by Elsevier B.V. under a Creative Commons license (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Pediatric multiple sclerosis, Demyelination seizures, 2017 McDonald diagnostic criteria, radiologically isolated syndrome (RIS) |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10145628 |
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