Redondo-Camos, Maria;
Cattaneo, Gabriele;
Perellon-Alfonso, Ruben;
Alviarez-Schulze, Vanessa;
Morris, Timothy P;
Solana-Sanchez, Javier;
Espana-Irla, Goretti;
... Bartres-Faz, David; + view all
(2022)
Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults.
Frontiers in Psychology
, 13
, Article 813444. 10.3389/fpsyg.2022.813444.
Preview |
Text
Zetterberg_Local Prefrontal Cortex TMS Induced Reactivity Is Related to Working Memory and Reasoning in Middle Aged Adults_VoR.pdf - Published Version Download (1MB) | Preview |
Abstract
Introduction: The prefrontal cortex (PFC) plays a crucial role in cognition, particularly in executive functions. Cortical reactivity measured with Transcranial Magnetic Stimulation combined with Electroencephalography (TMS-EEG) is altered in pathological conditions, and it may also be a marker of cognitive status in middle-aged adults. In this study, we investigated the associations between cognitive measures and TMS evoked EEG reactivity and explored whether the effects of this relationship were related to neurofilament light chain levels (NfL), a marker of neuroaxonal damage. Methods: Fifty two healthy middle-aged adults (41–65 years) from the Barcelona Brain Health Initiative cohort underwent TMS-EEG, a comprehensive neuropsychological assessment, and a blood test for NfL levels. Global and Local Mean-Field Power (GMFP/LMFP), two measures of cortical reactivity, were quantified after left prefrontal cortex (L-PFC) stimulation, and cognition was set as the outcome of the regression analysis. The left inferior parietal lobe (L-IPL) was used as a control stimulation condition. Results: Local reactivity was significantly associated with working memory and reasoning only after L-PFC stimulation. No associations were found between NfL and cognition. These specific associations were independent of the status of neuroaxonal damage indexed by the NfL biomarker and remained after adjusting for age, biological sex, and education. Conclusion: Our results demonstrate that TMS evoked EEG reactivity at the L-PFC, but not the L-IPL, is related to the cognitive status of middle-aged individuals and independent of NfL levels, and may become a valuable biomarker of frontal lobe-associated cognitive function.
| Type: | Article |
|---|---|
| Title: | Local Prefrontal Cortex TMS-Induced Reactivity Is Related to Working Memory and Reasoning in Middle-Aged Adults |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fpsyg.2022.813444 |
| Publisher version: | https://doi.org/10.3389/fpsyg.2022.813444 |
| Language: | English |
| Additional information: | Copyright © 2022 Redondo-Camós, Cattaneo, Perellón-Alfonso, Alviarez-Schulze, Morris, Solana-Sanchez, España-Irla, Delgado-Gallén, Pachón-García, Albu, Zetterberg, Tormos, Pascual-Leone and Bartres-Faz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Social Sciences, Psychology, Multidisciplinary, Psychology, transcranial magnetic stimulation (TMS), Electroencephalography, TMS-EEG, cortical reactivity, prefrontal cortex (PFC), cognition, TRANSCRANIAL MAGNETIC STIMULATION, CORTICAL EXCITABILITY, BRAIN-FUNCTION, COGNITION, EEG, MAINTENANCE, MODULATION, HANDEDNESS, HUMANS |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10145228 |
Archive Staff Only
 |
View Item |
