Balachandran, S;
Moni, M;
Sathyapalan, DT;
Varghese, P;
Jose, MP;
Murugan, MR;
Rajan, C;
... Menon, JC; + view all
(2022)
A comparison of clinical outcomes between vaccinated and vaccine-naive patients of COVID-19, in four tertiary care hospitals of Kerala, South India.
Clinical Epidemiology and Global Health
, 13
, Article 100971. 10.1016/j.cegh.2022.100971.
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Abstract
The problem considered: This multi-centric study analyzed data of COVID-19 patients and compared differences in symptomatology, management, and outcomes between vaccinated and vaccine-naive patients. Methods: All COVID-19 positive individuals treated as an in-or out-patient from the 1stMarch to 15th May 2021 in four selected study sites were considered for the study. Treatment details, symptoms, and clinical course were obtained from hospital records. Chi-square was used to test the association of socio-demographic and treatment variables with the vaccination status and binary logistic regression were used to obtain the odds ratio with a 95% confidence interval. Results: The analysis was of 1446 patients after exclusion of 156 with missing data of which males were 57.3% and females 42.7%. 346 were vaccinated; 189 received one dose and 157 both doses. Hospitalization was more in vaccinated (38.2% vs 27.4%); ICU admissions were less in vaccinated (3.5% vs 7.1%). More vaccinated were symptomatic (OR = 1.5); half less likely to be on non-invasive ventilation (OR = 0.5) while vaccine naive patients had 4.21 times the risk of death. Conclusion: Severe infection, duration of hospital stays, need for ventilation and death were significantly less among vaccinated when compared with vaccine naive patients.
| Type: | Article |
|---|---|
| Title: | A comparison of clinical outcomes between vaccinated and vaccine-naive patients of COVID-19, in four tertiary care hospitals of Kerala, South India |
| Location: | India |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cegh.2022.100971 |
| Publisher version: | https://doi.org/10.1016/j.cegh.2022.100971 |
| Language: | English |
| Additional information: | © 2022 The Author(s). Published by Elsevier B.V. on behalf of INDIACLEN. Available under the Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0) |
| Keywords: | COVID-19, Coronavirus, Outcomes, Vaccine, Vaccine-breakthrough infection |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10145151 |
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