Bonfanti, Alessandra;
Duque, Julia;
Kabla, Alexandre;
Charras, Guillaume;
(2022)
Fracture in living tissues.
Trends in Cell Biology
, 32
(6)
pp. 537-551.
10.1016/j.tcb.2022.01.005.
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Abstract
During development and in adult physiology, living tissues are continuously subjected to mechanical stresses originating either from cellular processes intrinsic to the tissue or from external forces. As a consequence, rupture is a constant risk and can arise as a result of excessive stresses or because of tissue weakening through genetic abnormalities or pathologies. Tissue fracture is a multiscale process involving the unzipping of intercellular adhesions at the molecular scale in response to stresses arising at the tissue or cellular scale that are transmitted to adhesion complexes via the cytoskeleton. In this review we detail experimental characterization and theoretical approaches for understanding the fracture of living tissues at the tissue, cellular, and molecular scales.
| Type: | Article |
|---|---|
| Title: | Fracture in living tissues |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tcb.2022.01.005 |
| Publisher version: | https://doi.org/10.1016/j.tcb.2022.01.005 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cadherin, cytoskeleton, desmosome, fracture |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10145011 |
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