Siddiqui, MF;
Pinti, P;
Lloyd-Fox, S;
Jones, EJH;
Brigadoi, S;
Collins-Jones, L;
Tachtsidis, I;
... Elwell, CE; + view all
(2022)
Regional Haemodynamic and Metabolic Coupling in Infants.
Frontiers in Human Neuroscience
, 15
, Article 780076. 10.3389/fnhum.2021.780076.
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Abstract
Metabolic pathways underlying brain function remain largely unexplored during neurodevelopment, predominantly due to the lack of feasible techniques for use with awake infants. Broadband near-infrared spectroscopy (bNIRS) provides the opportunity to explore the relationship between cerebral energy metabolism and blood oxygenation/haemodynamics through the measurement of changes in the oxidation state of mitochondrial respiratory chain enzyme cytochrome-c-oxidase (ΔoxCCO) alongside haemodynamic changes. We used a bNIRS system to measure ΔoxCCO and haemodynamics during functional activation in a group of 42 typically developing infants aged between 4 and 7 months. bNIRS measurements were made over the right hemisphere over temporal, parietal and central cortical regions, in response to social and non-social visual and auditory stimuli. Both ΔoxCCO and Δ[HbO2] displayed larger activation for the social condition in comparison to the non-social condition. Integration of haemodynamic and metabolic signals revealed networks of stimulus-selective cortical regions that were not apparent from analysis of the individual bNIRS signals. These results provide the first spatially resolved measures of cerebral metabolic activity alongside haemodynamics during functional activation in infants. Measuring synchronised changes in metabolism and haemodynamics have the potential for uncovering the development of cortical specialisation in early infancy.
| Type: | Article |
|---|---|
| Title: | Regional Haemodynamic and Metabolic Coupling in Infants |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnhum.2021.780076 |
| Publisher version: | https://doi.org/10.3389/fnhum.2021.780076 |
| Language: | English |
| Additional information: | Copyright © 2022 Siddiqui, Pinti, Lloyd-Fox, Jones, Brigadoi, Collins-Jones, Tachtsidis, Johnson and Elwell. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | metabolism, fNIRS (functional near infrared spectroscopy), neurovascular coupling, brain specialization, neurodevelopment, mitochondria, social brain, brain metabolic imaging |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10144608 |
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