Bhatnagar, Gauraang;
Mallett, Sue;
Quinn, Laura;
Beable, Richard;
Bungay, Helen;
Betts, Margaret;
Greenhalgh, Rebecca;
... Taylor, Stuart; + view all
(2022)
Interobserver variation in the interpretation of magnetic resonance enterography in Crohn's disease.
British Journal of Radiology
, 95
(1134)
, Article 20210995. 10.1259/bjr.20210995.
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Abstract
OBJECTIVES: To evaluate inter observer variability for diagnosis of disease presence and extent of small bowel and colonic Crohn's disease using MR enterography (MRE). METHODS: Data from the first 73 consecutive patients (mean age 32, 33F, 28 new diagnosis, 45 suspected relapse) recruited to a multicentre, prospective diagnostic accuracy trial evaluating MRE for small bowel Crohn's disease were each read independently by three (from a pool of twenty) radiologists. Radiologists documented presence and segmental location of small bowel Crohn's disease and recorded morphological mural/extra mural parameters for involved segments. Per patient percentage agreement for disease presence and extent were calculated against an outcome-based construct reference standard was calculated (averaged between pairs of readers). Prevalence adjusted bias adjusted κ (PABAK) was calculated. RESULTS: Agreement for small bowel disease presence for new diagnosis/relapsed patients was 68%(κ = 0.36)/ 78% (κ = 0.56) and for disease extent 43%(κ = 0.14)/ 53% for disease extent (κ = 0.07), respectively. For disease presence all three radiologists agreed correctly with the reference standard in 41/59 (69%) of patients with small bowel involvement, and in 8/14 (57%) cases of disease absence. Agreement was highest for multi segment disease, greater than 5 cm in length, with mural thickness >6 mm, and increased mural T2 signal. Agreement for colonic disease presence was 61% (κ = 0.21 fair agreement) for new diagnosis/ 60% (κ = 0.20, slight agreement) for relapsed patients. CONCLUSION: There is reasonable agreement between radiologists for small bowel disease presence using MRE for newly diagnosed Crohn's disease, and patients with suspected relapse respectively. Agreement is lower for disease extent. ADVANCES IN KNOWLEDGE: There is reasonable agreement between radiologists for small bowel disease presence using MRE for newly diagnosed (68%) Crohn's disease, and patients with suspected relapse (78%). Agreement is lower for disease extent (43% new diagnosis and 53% suspected relapse).
| Type: | Article |
|---|---|
| Title: | Interobserver variation in the interpretation of magnetic resonance enterography in Crohn's disease |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1259/bjr.20210995 |
| Publisher version: | https://doi.org/10.1259/bjr.20210995 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors. Published by the British Institute of Radiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10144525 |
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