Larsen, Lotte Hardbo;
Z'Graggen, Werner J;
Bostock, Hugh;
Tan, S Veronica;
Buus, Niels Henrik;
Tankisi, Hatice;
(2021)
The role of potassium in muscle membrane dysfunction in end-stage renal disease.
Clinical Neurophysiology
, 132
(12)
pp. 3125-3135.
10.1016/j.clinph.2021.09.012.
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Abstract
Objective: Uremic myopathy is a condition seen in end-stage renal disease (ESRD), characterized by muscle weakness and muscle fatigue, in which the pathophysiology is uncertain. The aim of this study was to assess the role of abnormal serum constituents in ESRD patients by relating them to the excitability properties of the tibialis anterior muscle, at rest and during electrically induced muscle activation, by recording muscle velocity recovery cycles (MVRC) and frequency ramp responses. Methods: Eighteen ESRD patients undergoing hemodialysis were evaluated by blood sample, MVRC, and frequency ramp (before and near the end of dialysis treatment), quantitative electromyography, and nerve conduction studies. Patients were compared to 24 control subjects. Results: In patients, muscle relative refractory period, early supernormality, late supernormality after 5 conditioning stimuli, and latency of the last of 15 and 30 frequency ramp pulses were strongly associated with potassium levels (p < 0.01), showing depolarization before and normalization in the end of hemodialysis. Conclusions: In ESRD patients, the muscle membrane is depolarized, mainly due to hyperkalemia. Significance: Since normal muscle fatigue has been attributed to potassium-induced depolarization, it seems likely that this mechanism is also a major cause of the exaggerated muscle fatigue and weakness in ESRD patients.
| Type: | Article |
|---|---|
| Title: | The role of potassium in muscle membrane dysfunction in end-stage renal disease |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clinph.2021.09.012 |
| Publisher version: | https://doi.org/10.1016/j.clinph.2021.09.012 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Muscle velocity recovery cycles, Frequency ramp, Electromyography, Uremic myopathy, End-stage renal disease, Hemodialysis, Hyperkalemia, VELOCITY RECOVERY CYCLES, UNIT NUMBER ESTIMATION, IN-VIVO ASSESSMENT, SKELETAL-MUSCLE, ACTION-POTENTIALS, NEUROLOGIC MANIFESTATIONS, MYOPATHY, HYPERKALEMIA, RECORDINGS, UREMIA |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10144492 |
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