Gil Rosa, B;
Akingbade, OE;
Guo, X;
Gonzalez-Macia, L;
Crone, MA;
Cameron, LP;
Freemont, P;
... Li, B; + view all
(2022)
Multiplexed immunosensors for point-of-care diagnostic applications.
Biosensors and Bioelectronics
, 203
, Article 114050. 10.1016/j.bios.2022.114050.
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Abstract
Accurate, reliable, and cost-effective immunosensors are clinically important for the early diagnosis and monitoring of progressive diseases, and multiplexed sensing is a promising strategy for the next generation of diagnostics. This strategy allows for the simultaneous detection and quantification of multiple biomarkers with significantly enhanced reproducibility and reliability, whilst requiring smaller sample volumes, fewer materials, and shorter average analysis time for individual biomarkers than individual tests. In this opinionated review, we compare different techniques for the development of multiplexed immunosensors. We review the state-of-the-art approaches in the field of multiplexed immunosensors using electrical, electrochemical, and optical methods. The barriers that prevent translating this sensing strategy into clinics are outlined together with the potential solutions. We also share our vision on how multiplexed immunosensors will continue their evolution in the coming years.
| Type: | Article |
|---|---|
| Title: | Multiplexed immunosensors for point-of-care diagnostic applications |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bios.2022.114050 |
| Publisher version: | https://doi.org/10.1016/j.bios.2022.114050 |
| Language: | English |
| Additional information: | Copyright © 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office > Institute for Materials Discovery UCL > Provost and Vice Provost Offices > UCL BEAMS UCL UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10143749 |
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