Yerramalla, Manasa Shanta;
van Hees, Vincent T;
Chen, Mathilde;
Fayosse, Aurore;
Chastin, Sebastien FM;
Sabia, Séverine;
(2022)
Objectively measured total sedentary time and pattern of sedentary accumulation in older adults: associations with incident cardiovascular disease and all-cause mortality.
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
, Article glac023. 10.1093/gerona/glac023.
(In press).
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Abstract
BACKGROUND: We examined associations of total duration and pattern of accumulation of objectively-measured sedentary behaviour (SB) with incident cardiovascular disease (CVD) and all-cause mortality among older adults. METHODS: Total sedentary time and eight sedentary accumulation pattern metrics were extracted from accelerometer data of 3991 Whitehall II study participants aged 60-83 years in 2012-2013. Incident CVD and all-cause mortality were ascertained up to March 2019. RESULTS: 299 CVD cases and 260 deaths were recorded over a mean (standard deviation) follow-up of 6.2 (1.3) and 6.4 (0.8) years, respectively. Adjusting for sociodemographic and behavioural factors, 1-SD (100.2 minutes) increase in total sedentary time was associated with 20% higher CVD risk (Hazard Ratio (95% confidence interval): 1.20 (1.05-1.37)). More fragmented SB was associated with reduced CVD risk (e.g. 0.86 (0.76-0.97) for 1-SD (6.2) increase in breaks per sedentary hour). Associations were not evident once health-related factors and moderate-to-vigorous physical activity (MVPA) were considered. For all-cause mortality, associations with more fragmented SB (e.g. 0.73 (0.59-0.91) for breaks per sedentary hour) were found only among the youngest older group (<74 years; p for interaction with age<0.01) independently from all covariates. CONCLUSIONS: In this study, no associations of total sedentary time and sedentary accumulation patterns with incident CVD and all-cause mortality were found in the total sample once MVPA was considered. Our findings of reduced mortality risk with less total and more fragmented SB independent from MVPA among individuals <74 years need to be replicated to support the recent recommendations to reduce and fragment SB.
| Type: | Article |
|---|---|
| Title: | Objectively measured total sedentary time and pattern of sedentary accumulation in older adults: associations with incident cardiovascular disease and all-cause mortality |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/gerona/glac023 |
| Publisher version: | https://doi.org/10.1093/gerona/glac023 |
| Language: | English |
| Additional information: | © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Accelerometer, Breaks in sedentary behaviour, Moderate-to-vigorous physical activity, Prospective |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10143252 |
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