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Milestones in Tremor Research: 10 Years Later

Erro, Roberto; Fasano, Alfonso; Barone, Paolo; Bhatia, Kailash P; (2022) Milestones in Tremor Research: 10 Years Later. Movement Disorders Clinical Practice , 9 (4) pp. 429-435. 10.1002/mdc3.13418. Green open access

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Abstract

Major progress has occurred during the last decade in the field of tremor. From the clinical standpoint, a new classification has completely revised the nosology of tremor syndromes and has re-conceptualized Essential Tremor as a syndrome rather than a single disease entity, fueling an ongoing enlightened debate. Significant advances have been obtained in terms of instrumental measurement of tremor, remarking on the possibility of developing novel treatment strategies based on tremor characteristics, namely tremor-phase. Moreover, a better understanding of the pathophysiological mechanisms has further led to the suggestion of refining the classification of tremor syndromes according to their driving underpinnings. Finally, surgical options such as deep brain stimulation and focused ultrasound thalamotomy are now part of the therapeutic portfolio for tremor, but several oral drugs, including long-chain alcohols, T-channel blockers, allosteric modulators of potassium channels and of GABA-A receptors, are currently being tested and hold promise. This review will discuss the key milestones in tremor research of the last ten years, with a focus on the most common tremor syndromes, namely Essential Tremor, Dystonic Tremor and Parkinsonian Tremor.

Type: Article
Title: Milestones in Tremor Research: 10 Years Later
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mdc3.13418
Publisher version: https://doi.org/10.1002/mdc3.13418
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions
Keywords: Essential tremor, dystonic tremor, parkinson disease, sensors, MRgFUS
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10143243
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