Padovani, Alessandro;
Canale, Antonio;
Schiavon, Lorenzo;
Masciocchi, Stefano;
Imarisio, Alberto;
Risi, Barbara;
Bonzi, Giulio;
... Pilotto, Andrea; + view all
(2022)
Is amyloid involved in acute neuroinflammation? A CSF analysis in encephalitis.
Alzheimer's & Dementia
10.1002/alz.12554.
(In press).
Preview |
Text
Zetterberg_Is amyloid involved in acute neuroinflammation A CSF analysis in encephalitis.pdf - Published Version Download (1MB) | Preview |
Abstract
INTRODUCTION: Several investigations have argued for a strong relationship between neuroinflammation and amyloid metabolism but it is still unclear whether inflammation exerts a pro-amyloidogenic effect, amplifies the neurotoxic effect of amyloid, or is protective. METHODS: Forty-two patients with acute encephalitis (ENC) and 18 controls underwent an extended cerebrospinal fluid (CSF) panel of inflammatory, amyloid (Aβ40, 42, and 38, sAPP-α, sAPP-β), glial, and neuronal biomarkers. Linear and non-linear correlations between CSF biomarkers were evaluated studying conditional independence relationships. RESULTS: CSF levels of inflammatory cytokines and neuronal/glial markers were higher in ENC compared to controls, whereas the levels of amyloid-related markers did not differ. Inflammatory markers were not associated with amyloid markers but exhibited a correlation with glial and neuronal markers in conditional independence analysis. DISCUSSION: By an extensive CSF biomarkers analysis, this study showed that an acute neuroinflammation state, which is associated with glial activation and neuronal damage, does not influence amyloid homeostasis.
| Type: | Article |
|---|---|
| Title: | Is amyloid involved in acute neuroinflammation? A CSF analysis in encephalitis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.12554 |
| Publisher version: | https://doi.org/10.1002/alz.12554 |
| Language: | English |
| Additional information: | © 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/). |
| Keywords: | acute inflammation, amyloid, glial cells, neuroinflammation, tau |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10143226 |
Archive Staff Only
 |
View Item |
