Andrews, Derek Sayre;
Aksman, Leon;
Kerns, Connor M;
Lee, Joshua K;
Winder-Patel, Breanna M;
Harvey, Danielle Jenine;
Waizbard-Bartov, Einat;
... Amaral, David G; + view all
(2022)
Association of Amygdala Development with Different Forms of Anxiety in Autism Spectrum Disorder.
Biological Psychiatry
10.1016/j.biopsych.2022.01.016.
(In press).
Preview |
Text
1-s2.0-S0006322322000580-main.pdf Download (759kB) | Preview |
Abstract
Background: The amygdala is widely implicated in both anxiety and autism spectrum disorder. However, no studies have investigated the relationship between co-occurring anxiety and longitudinal amygdala development in autism. Here, the authors characterize amygdala development across childhood in autistic children with and without traditional DSM forms of anxiety and anxieties distinctly related to autism. Methods: Longitudinal MRI scans were acquired at up to four timepoints for 71 autistic and 55 typically developing (TD) children (∼2.5-12 years, 411 timepoints). Traditional DSM anxiety and anxieties distinctly related to autism were assessed at study Time 4 (∼8-12 years) using a diagnostic interview tailored to autism: The Anxiety Disorders Interview Schedule-IV with the Autism Spectrum Addendum. Mixed effects models were used to test group differences at study Time 1 (3.18 years), Time 4 (11.36 years), and developmental differences (age-by-group interactions) in right and left amygdala volume between autistic children with and without DSM or autism distinct anxieties, and TD. Results: Autistic children with DSM anxiety had significantly larger right amygdala volumes compared to TD at both study Time 1 (5.10% increase) and Time 4 (6.11% increase). Autistic children with autism distinct anxieties had significantly slower right amygdala growth compared to TD, autism-no anxiety, and autism-DSM anxiety groups and smaller right amygdala volumes at Time 4 compared to the autism-no anxiety (-8.13% decrease) and autism-DSM anxiety (-12.05% decrease) groups. Conclusions: Disparate amygdala volumes and developmental trajectories between DSM and autism distinct forms of anxiety suggest different biological underpinnings for these common, co-occurring conditions in autism.
| Type: | Article |
|---|---|
| Title: | Association of Amygdala Development with Different Forms of Anxiety in Autism Spectrum Disorder |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.biopsych.2022.01.016 |
| Publisher version: | https://doi.org/10.1016/j.biopsych.2022.01.016 |
| Language: | English |
| Additional information: | © 2022 Published by Elsevier Inc on behalf of Society of Biological Psychiatry. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| Keywords: | Autism, anxiety, MRI, longitudinal, brain, development |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10143027 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
