Xu, Rui;
O'Reilly, Meaghan Anne;
(2021)
Array-Based Beamforming to the Vertebral Canal: Demonstration of Feasibility.
In:
IEEE International Ultrasonics Symposium, IUS.
IEEE
(In press).
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Abstract
Focused ultrasound blood-spinal cord barrier opening is a promising new method for improving the non-invasive delivery of therapeutic agents to the spinal cord. A custom 64-element phased array was built, based on the design of a component of a spine-specific array for focusing ultrasound through vertebral laminae and correcting vertebra-induced distortions. Geometric and hydrophone delays were tested in each thoracic vertebra in an ex vivo spine (n=12). Pressure fields were measured in each canal to measure focal aberrations. Geometric delays produced foci shifted by 2.4±1.7 mm from the target, while hydrophone delays produced foci 1.3±1.1 mm from the target. Simulation showed good correlation with hydrophone delays and may be a viable non-invasive method for phase corrections. This work demonstrates the feasibility of transvertebral ultrasound beamforming with a phased-array.
| Type: | Proceedings paper |
|---|---|
| Title: | Array-Based Beamforming to the Vertebral Canal: Demonstration of Feasibility |
| Event: | 2021 IEEE International Ultrasonics Symposium (IUS) |
| Dates: | 11 Sep 2021 - 16 Sep 2021 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/IUS52206.2021.9593839 |
| Publisher version: | https://doi.org/10.1109/IUS52206.2021.9593839 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10143014 |
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