Yao, Yanting;
Wu, Mengmeng;
Wang, Lina;
Lin, Longnian;
Xu, Jiamin;
(2020)
Phase Coupled Firing of Prefrontal Parvalbumin Interneuron With High Frequency Oscillations.
Frontiers in Cellular Neuroscience
, 14
, Article 610741. 10.3389/fncel.2020.610741.
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Abstract
The prefrontal cortex (PFC) plays a central role in executive functions and inhibitory control over many cognitive behaviors. Dynamic changes in local field potentials (LFPs), such as gamma oscillation, have been hypothesized to be important for attentive behaviors and modulated by local interneurons such as parvalbumin (PV) cells. However, the precise relationships between the firing patterns of PV interneurons and temporal dynamics of PFC activities remains elusive. In this study, by combining in vivo electrophysiological recordings with optogenetics, we investigated the activities of prefrontal PV interneurons and categorized them into three subtypes based on their distinct firing rates under different behavioral states. Interestingly, all the three subtypes of interneurons showed strong phase-locked firing to cortical high frequency oscillations (HFOs), but not to theta or gamma oscillations, despite of behavior states. Moreover, we showed that sustained optogenetic stimulation (over a period of 10 s) of PV interneurons can consequently modulate the activities of local pyramidal neurons. Interestingly, such optogenetic manipulations only showed moderate effects on LFPs in the PFC. We conclude that prefrontal PV interneurons are consist of several subclasses of cells with distinct state-dependent modulation of firing rates, selectively coupled to HFOs.
Type: | Article |
---|---|
Title: | Phase Coupled Firing of Prefrontal Parvalbumin Interneuron With High Frequency Oscillations |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.3389/fncel.2020.610741 |
Publisher version: | https://doi.org/10.3389/fncel.2020.610741 |
Language: | English |
Additional information: | © 2020 Yao, Wu, Wang, Lin and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). |
Keywords: | optogenetics, prefrontal cortex, parvalbumin interneurons, firing pattern, high frequency oscillation |
UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
URI: | https://discovery.ucl.ac.uk/id/eprint/10142808 |




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