Sing, Chor-Wing;
Tang, Casey Tse Lam;
Chui, Celine Sze Ling;
Fan, Min;
Lai, Francisco Tsz Tsun;
Li, Xue;
Wan, Eric Yuk Fai;
... Wong, Ian Chi Kei; + view all
(2022)
COVID-19 vaccines and risks of hematological abnormalities: nested case-control and self-controlled case series study.
American Journal of Hematology
, 97
(4)
pp. 470-480.
10.1002/ajh.26478.
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Abstract
BACKGROUND: Several studies reported hematological abnormalities after vaccination against the coronavirus disease 2019 (COVID-19). We evaluated the association between COVID-19 vaccines (CoronaVac and BNT162b2) and hematological abnormalities. METHODS: We conducted nested case-control and self-controlled case series (SCCS) analyses using the data from the Hong Kong Hospital Authority and the Department of Health, HKSAR. Outcomes of interest were thrombocytopenia, leukopenia, and neutropenia. Adjusted odds ratios (aORs), incidence rate ratios (IRRs), and 95% confidence intervals (CIs) were estimated using conditional logistic regression. RESULTS: In total, 1,643,419 people received COVID-19 vaccination (738,609 CoronaVac; 904,810 BNT162b2). We identified 457 and 422 cases after CoronaVac and BNT162b2 vaccination, respectively. For CoronaVac, the incidence of thrombocytopenia, leukopenia, and neutropenia was 2.51, 1.08, 0.15 per 10,000 doses. For BNT162b2, the corresponding incidence were 1.39, 1.17, 0.26 per 10,000 doses. The incidence per 10,000 COVID-19 cases were 1,254, 2,341, and 884, respectively. We only observed an increased risk of leukopenia following the second dose of BNT162b2 (aOR 1.58, 95% CI 1.24 - 2.02; day0-14, IRR 2.21; 95% CI 1.59-3.08). There was no increased risk of any hematological abnormalities after CoronaVac vaccination. CONCLUSION: We observed an increased risk of leukopenia shortly after the second dose of BNT162b2. However, the incidence was much lower than the incidence following SARS-COV-2 infections. There was no association between CoronaVac and hematological abnormalities. The benefits of vaccination against COVID-19 still outweigh the risk of hematological abnormalities.
| Type: | Article |
|---|---|
| Title: | COVID-19 vaccines and risks of hematological abnormalities: nested case-control and self-controlled case series study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ajh.26478 |
| Publisher version: | https://doi.org/10.1002/ajh.26478 |
| Language: | English |
| Additional information: | © 2022 The Authors. American Journal of Hematology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | COVID-19, hematology, leukopenia, neutropenia, thrombocytopenia, vaccination |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10142624 |
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