McDowell, AR;
Petrova, N;
Carassiti, D;
Miquel, ME;
Thomas, DL;
Barker, GJ;
Schmierer, K;
(2022)
High-resolution quantitative MRI of multiple sclerosis spinal cord lesions.
Magnetic Resonance in Medicine
10.1002/mrm.29152.
(In press).
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Abstract
Purpose: Validation of quantitative MR measuresfor myelin imaging in the postmortem multiple sclerosis spinal cord. Methods: Four fixed spinal cord samples were imaged first with a 3T clinical MR scannerto identify areas of interest forscanning, and then with a 7T small bore scanner using a multicomponent-driven equilibrium single-pulse observation of T1 and T2 protocol to produce apparent proton density, T1, T2, myelin water, intracellular water, and free-water fraction maps. After imaging, the cords were sectioned and stained with histological markers (hematoxylin and eosin, myelin basic protein, and neurofilament protein), which were quantitatively compared with the MR maps. Results: Excellent correspondence was found between high-resolution MR parameter maps and histology, particularly for apparent proton density MRI and myelin basic protein staining. Conclusion: High-resolution quantitative MRI of the spinal cord provides biologically meaningful measures, and could be beneficial to diagnose and track multiple sclerosis lesions in the spinal cord.
| Type: | Article |
|---|---|
| Title: | High-resolution quantitative MRI of multiple sclerosis spinal cord lesions |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.29152 |
| Publisher version: | https://doi.org/10.1002/mrm.29152 |
| Language: | English |
| Additional information: | © 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | multiple sclerosis, myelin water fraction, spinal cord, WHITE-MATTER DEVELOPMENT, MYELIN WATER FRACTION, STEADY-STATE, MAGNETIC-RESONANCE, BRAIN, RELAXATION, DISABILITY, DIAGNOSIS, TIME, T-1 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10142126 |
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