Lewis-Thompson, I;
Zhang, S;
Noimark, S;
Desjardins, AE;
Colchester, RJ;
(2022)
PDMS composites with photostable NIR dyes for multi-modal ultrasound imaging.
MRS Advances
10.1557/s43580-022-00208-3.
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Abstract
All-optical ultrasound (OpUS) imaging has emerged as an imaging paradigm well-suited for minimally invasive surgical procedures. With this modality, ultrasound is generated when pulsed or modulated light is absorbed within a coating material. By engineering wavelength-selective coatings, complementary imaging and therapeutic modalities can be integrated with OpUS. Here, we present a wavelength-selective composite material comprising a near-infrared absorbing dye and polydimethylsiloxane. The optical absorption for this material peaked in the vicinity of 1064 nm, with up to 91% of incident light being absorbed, whilst maintaining lower optical absorption at other wavelengths. This material was used to generate ultrasound, demonstrating ultrasound pressures >1 MPa, consistent with those used for imaging applications. Crucially, long exposure photostability and device performance were found to be stable over a one hour period (peak pressure variation <10%), longer than required for standard clinical imaging applications.
| Type: | Article |
|---|---|
| Title: | PDMS composites with photostable NIR dyes for multi-modal ultrasound imaging |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1557/s43580-022-00208-3 |
| Publisher version: | https://doi.org/10.1557/s43580-022-00208-3 |
| Language: | English |
| Additional information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Composite, Polydimethylsiloxane, Organic dyes, Optical absorption, Photostability, Ultrasound |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10142116 |
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