Russell, LL;
Greaves, CV;
Convery, RS;
Bocchetta, M;
Warren, JD;
Kaski, D;
Rohrer, JD;
(2021)
Eye movements in frontotemporal dementia: Abnormalities of fixation, saccades and anti-saccades.
Alzheimer's & Dementia: Translational Research & Clinical Interventions
, 7
(1)
, Article e12218. 10.1002/trc2.12218.
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A D Transl Res Clin Interv - 2022 - Russell - Eye movements in frontotemporal dementia Abnormalities of fixation .pdf - Published Version Download (1MB) | Preview |
Abstract
Introduction: Oculomotor function has not been systematically studied in frontotemporal dementia (FTD) and yet may offer a simple target to monitor disease activity. Methods: We assessed fixation stability, smooth pursuit, pro-saccades, and anti-saccades using the Eyelink 1000-plus eye-tracker in 19 individuals with behavioral variant FTD (bvFTD) and 22 controls. Neuroanatomical correlates were assessed using a region of interest magnetic resonance imaging (MRI) analysis. Results: Measures of fixation stability were impaired in the bvFTD group compared with controls. However, performance did not differ from controls in the pro-saccade tasks except in the vertical overlap condition. The bvFTD group performed worse in the anti-saccade task, which correlated strongly with executive function. Neural correlates included the orbitofrontal and ventromedial prefrontal cortices and striatum for fixation stability, and the dorsolateral prefrontal and parietal cortices and striatum for anti-saccades. Discussion: Overall, oculomotor function is abnormal in bvFTD, with performance likely related to impairment of inhibitory control and executive dysfunction.
| Type: | Article |
|---|---|
| Title: | Eye movements in frontotemporal dementia: Abnormalities of fixation, saccades and anti-saccades |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/trc2.12218 |
| Publisher version: | https://doi.org/10.1002/trc2.12218 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: | Anti‐saccades, behavioral variant frontotemporal dementia, eye‐tracking, fixations, oculomotor function, pursuit, saccades |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10141861 |
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