Kiani-Alikhan, S;
Walker, E;
Hickey, A;
Grigoriadou, S;
Buckland, M;
Scott, C;
(2021)
Measurement of C1-Inhibitor function alone is sufficient for diagnosis of hereditary angioedema.
Journal of Clinical Pathology
10.1136/jclinpath-2021-207538.
(In press).
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Abstract
The World Allergy Organisiation/European Academy of Allergy and Clinical Immunology (WAO/EAACI) 2017/2018 guidelines recommend measuring complement4 levels, followed by C1-inhibitor level and function for diagnosis of hereditary angioedema (HAE). We analysed 6 months’ worth of data generated in our laboratory which is a specialist regional immunology service and also provides laboratory service for the Barts Health immunology department, which is a GA2LEN/HAEi-Angioedema Centre of Excellence and Reference (ACARE) and hence, investigates a large number of patients for HAE. We found that an efficient and sensitive approach for laboratory diagnosis of HAE is to only test the C1-inhibitor function. This approach had a sensitivity of 100% and reduced the cost of laboratory investigations for HAE diagnosis by 45%.
| Type: | Article |
|---|---|
| Title: | Measurement of C1-Inhibitor function alone is sufficient for diagnosis of hereditary angioedema |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/jclinpath-2021-207538 |
| Publisher version: | http://dx.doi.org/10.1136/jclinpath-2021-207538 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Pathology, complement system proteins, medical laboratory science, skin, immune system diseases, diagnosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10141714 |
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