Sakai, NS;
Bhagwanani, A;
Bray, TJP;
Hall-Craggs, MA;
Taylor, SA;
(2021)
Assessment of body composition and association with clinical outcomes in patients with lung and colorectal cancer.
BJR|Open
, 3
(1)
10.1259/bjro.20210048.
Preview |
Text
bjro.20210048.pdf - Published Version Download (275kB) | Preview |
Abstract
OBJECTIVES: To assess body composition in patients with non-small cell lung cancer (NSCLC) and colorectal cancer using whole-body MRI and relate this to clinical outcomes. METHODS: 53 patients with NSCLC (28 males, 25 females; mean age 66.9) and 74 patients with colorectal cancer (42 males, 32 females; mean age 62.9) underwent staging whole-body MRI scans, which were post-processed to derive fat mass (FM), fat free mass (FFM) and skeletal muscle (SM) indices and SM fat fraction (FF). These were compared between the two cancer cohorts using two-sided t-tests and the chi-squared test. Measurements of body composition were correlated with outcomes including length of hospital stay, metastatic status and mortality. RESULTS: Patients with NSCLC had significantly lower FFM (p = 0.0071) and SM (p = 0.0084) indices. Mean SM FF was greater in patients with NSCLC (p = 0.0124) and was associated with longer hospital stay (p = 0.035). There was no significant relationship between FM, FFM and SM indices and length of hospital stay, metastatic status or mortality. CONCLUSIONS: Patients with NSCLC had lower FFM and SM indices than patients with colorectal cancer and greater SMFF, indicating lower SM mass with fatty infiltration. These findings reflect differences in the phenotype of the two groups and suggest patients with lung cancer are more likely to require additional nutritional support. ADVANCES IN KNOWLEDGE: Body composition differs between NSCLC and colorectal cancer. Patients with NSCLC have both a reduced SM mass and greater SM FF suggesting that they are more nutritionally deplete than patients with colorectal cancer.
| Type: | Article |
|---|---|
| Title: | Assessment of body composition and association with clinical outcomes in patients with lung and colorectal cancer |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1259/bjro.20210048 |
| Publisher version: | https://doi.org/10.1259/bjro.20210048 |
| Language: | English |
| Additional information: | © 2021 The Authors. Published by the British Institute of Radiology. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10141437 |
Loading...
Loading...Loading...| 1. |  China | 2 |
| 2. |  Russian Federation | 2 |
| 3. |  Germany | 2 |
| 4. |  United States | 2 |
| 5. |  United Kingdom | 1 |
Archive Staff Only
 |
View Item |
