Fatima, T;
Jacobsson, LTH;
Kern, S;
Zettergren, A;
Blennow, K;
Zetterberg, H;
Johansson, L;
... Skoog, I; + view all
(2021)
Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds.
Alzheimers Dementia
, 13
(1)
, Article e12241. 10.1002/dad2.12241.
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Abstract
Introduction: The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated. Methods: We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)42, Aβ40, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Aβ42/Aβ40 ratio, in cognitively unimpaired 70-year-old individuals from Gothenburg, Sweden. We also evaluated whether possible associations were modulated by the apolipoprotein E (APOE) ε4 allele. Results: Serum urate was positively associated with Aβ42 in males (β = 0.55 pg/mL, P = .04). There was a positive urate-APOE ε4 interaction (1.24 pg/mL, P interaction = .02) in relation to Aβ42 association. The positive urate and Aβ42 association strengthened in male APOE ε4 carriers (β = 1.28 pg/mL, P = .01). Discussion: The positive association between urate and Aβ42 in cognitively healthy men may suggest a protective effect of urate against deposition of amyloid protein in the brain parenchyma, and in the longer term, maybe against AD dementia.
| Type: | Article |
|---|---|
| Title: | Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/dad2.12241 |
| Publisher version: | https://doi.org/10.1002/dad2.12241 |
| Language: | English |
| Additional information: | © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | Alzheimer's disease, apolipoprotein E ε4, cerebrospinal fluid biomarkers, dementia, urate |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10141178 |
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